Lukas Naumann | Scientist - Analytical Chemistry (PAT)
Roche
Dr. Lukas Naumann is a dedicated Scientist specializing in Analytical Chemistry with a focus on Process Analytical Technology (PAT) at Roche. With a strong background in biochemistry and pharmaceutical sciences, Lukas brings a wealth of expertise to the field of biologics. His research interests lie in developing innovative analytical methods to optimize bioprocessing and ensure the quality and efficacy of biologic drugs.
Having worked at Roche, a global leader in healthcare, Lukas has been involved in cutting-edge projects that push the boundaries of biologics development. His contributions to the field of analytical chemistry have been instrumental in advancing the understanding of complex biological systems and improving the efficiency of bioproduction processes.
Lukas is a passionate advocate for collaboration and knowledge sharing in the scientific community. His presentations at conferences like the Festival of Biologics Basel 2025 provide valuable insights into the latest trends and developments in biologics research. With a commitment to excellence and a drive for continuous improvement, Dr. Lukas Naumann is a key player in shaping the future of innovative & fast chromatographic methods for PAT applications.
Appearances:
Festival of Biologics Day 2 @ 14:20
Expediting Online Liquid Chromatography for Real-Time Monitoring in Downstream Processing of Biopharmaceuticals
The application of Process Analytical Technology (PAT) principles for manufacturing of biotherapeutics proffers the prospect of ensuring consistent product quality along with increased productivity as well as substantial cost and time savings. Although this paradigm shift from a traditional, rather rigid manufacturing model to a more scientific, risk-based approach has been advocated by health authorities for almost two decades, the practical implementation of PAT in the biopharmaceutical industry is still limited by the lack of fit-for-purpose analytical methods. In this regard, most of the proposed spectroscopic techniques are sufficiently fast but exhibit deficiencies in terms of selectivity and sensitivity, while well-established offline methods, such as (ultra-)high-performance liquid chromatography, are generally considered as too slow for this task. To address these reservations, we introduce here a novel online Liquid Chromatography (LC) setup that was specifically designed to enable real-time monitoring of critical product quality attributes during time-sensitive purification operations in downstream processing. Furthermore, we will highlight the expansive opportunities of online LC based applications to serve as a PAT tool for biopharmaceutical manufacturing.
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