Yi-Ru Yu | Lead Scientist
Pilatus Biosciences SA
Dr. Yi-Ru Yu is currently a Senior Scientist at Pilatus Biosciences SA. He obtained his B.S. in Life Science and M.S. in Genomic Science from National Yang-Ming University in 2008. Dr. Yu then pursued a Ph.D. in Prof. Chun-Ming Chen's lab, where his research focused on the congenital diseases and tumorigenesis. In 2018, seeking to broaden his scientific expertise, Dr. Yu joined Prof. Ping-Chih Ho's lab at the University of Lausanne. There, he investigated cancer immunology, particularly the role of mitochondrial dynamics in the development of exhausted tumor-infiltrating CD8+ T cells. In 2022, Dr. Yu began a new chapter in his scientific career at Pilatus Biosciences. As the lead scientist, he focuses on translational medicine studies. He designs, coordinates, and establishes various collaborative studies with both academic institutes and CRO companies for pre-clinical studies.
Appearances:
Festival of Biologics Day 3 @ 11:50
A Single Punch to Rewire Immunity: Reprogramming the Tumor Microenvironment via Metabolic Intervention
- PLT012, a monoclonal antibody blocking CD36-mediated lipid uptake, demonstrated strong anti-tumor activity in liver malignancies with durable protection.
- PLT012 remodels the tumor microenvironment through reduction of immunosuppressive cell populations and simultaneously boost effector cell populations with remarkable safety profile.
- Pilatus has established a robust translational framework—including ex vivo patient-derived tumor fragment testing, in silico analysis, and multiplex staining—to explore predictive biomarkers. This strategy supports rational patient stratification and increases the likelihood of clinical trial success before entering FIH.
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